
Transmitter Cond/Res 2-Channel M300 33
© 05/07 Mettler-Toledo AG, CH-8606 Greifensee, Switzerland Transmitter Cond/Res 2-Channel M300
Printed in Switzerland 52 121 318
8.4 Setpoints
(PATH: Menu/Configure/Setpoints)
Enter configuration mode as described in Section 8.2.
Press the [ENTER] key to select this Menu.
Up to 4 Setpoints on a single channel transmitter and 6 on dual channel transmitters can be
configured on any of the measurements (a thru d). If configuring a setpoint for a measurement
displaying conductivity, the possible types are Off, High, Low, Outside and Between. Thornton
models also include types, %USP, %EP PW and %EP WFI. If configuring a setpoint for a chan-
nel displaying temperature, possible types are Off, High, Low, Outside and Between.
An ‘Outside’ Setpoint will cause an alarm condition whenever the measurement goes above its
high limit or below its low limit. A ‘Between’ Setpoint will cause an alarm condition to occur
whenever the measurement is between its high and low limits.
USP and EP Setpoints on Thornton models provide a high alarm used for pharmaceutical water
monitoring with non-temperature compensated conductivity measurements. USP (United States
Pharmacopoeia) section 〈645〉 and European Pharmacopoeia require that non-temperature
compensated conductivity of pharmaceutical waters must be below a limit from tables based
on the temperature of the sample. In other words, pharmaceutical requirements temperature-
compensate the limit rather than the measurement.
The Mettler Toledo Thornton M300 has these pharmaceutical limit tables in memory and auto-
matically determines the conductivity limit based on the measured temperature. USP and EPWFI
(Water for Injection) setpoints use Table 8.1. The limit is the conductivity value corresponding to
the 5° temperature step immediately below or equal to the measured temperature value. EP
Highly Purified Water limits are identical to EP WFI limits.
EP PW (Purified Water) setpoints use Table 8.2. The limit in this case is the conductivity value
interpolated for the measured temperature. The M300 takes care of this automatically.
The pharmaceutical setpoint value entered into the M300 is the percentage safety margin
below the limits to activate the setpoint. For example, the USP table conductivity limit at 15°C
is 1.0 µS/cm. If the setpoint value is set at 40% then the setpoint will activate whenever the
conductivity goes above 0.6 µS/cm at 15°C.
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